Titin is a protein that in humans is encoded by the TTN gene. 463 . [30] The gene duplication events took place independently but were from the same ancestral Ig and FNIII domains. The longest known word in English, at 189,819 letters, is the chemical name of titin. In terms of the traditional Welsh alphabet, the name is only 51 letters long, as certain digraphs in Welsh are considered as single letters, for instance ll, ng and ch. The elasticity of the PEVK region has both entropic and enthalpic contributions and is characterized by a polymer persistence length and a stretch modulus. Parastratiosphecomyia stratiosphecomyioides is the longest accepted binomial name. Zhixia Zhong, ... Kris Noel Dahl, in Methods in Cell Biology, 2010. [47] Further research also suggests that no genetically linked form of any dystrophy or myopathy can be safely excluded from being caused by a mutation on the TTN gene. Some people have heard of the protein(I think it's a protein) - Titin. [8] These domains unfold when the protein is stretched and refold when the tension is removed. The name titin is derived … [39] There also exists a titin homologue, ttn-1, in C. The length of a word may also be understood in multiple ways. As it appears nowhere else except in reference to this passage, it is generally not accepted as a real word. The chemical formula is: C 132983 H 211861 N 36149 O 40883 S 693. The name titin is derived from the Greek Titan (a giant deity, anything of great size). [16] Two years later, Kuan Wang and coworkers identified a doublet band on electrophoresis gel corresponding to a high molecular weight, elastic protein which they named titin. [17][18], Siegfried Labeit in 1990 isolated a partial cDNA clone of titin. The other end of titin … It is a species of soldier fly. [29] It is “stretch-sensitive” and helps repair overstretching of the sarcomere. [22] The protein's in vivo half-life, the time it takes for half of the amount of protein in a cell to break down after its synthesis in the cell, is predicted to be approximately 30 hours (in mammalian reticulocytes).[21]. [45], Titin interacts with many sarcomeric proteins including:[14], Mutations anywhere within the unusually long sequence of this gene can cause premature stop codons or other defects. Your task is to output this entire name! The full-length scientific name of this protein … Attempts to say the entire word have taken two, Technical; not in dictionary; whether this is a word is disputed, Technical; contrived coinage to make it the longest word, Unclear in source work, has been cited as a, Longest non-contrived word in a major dictionary, The act of regarding something as unimportant, Longest non-contrived and nontechnical word. The longest non-contrived place name in the United Kingdom which is a single non-hyphenated word is Cottonshopeburnfoot (19 letters) and the longest which is hyphenated is Sutton-under-Whitestonecliffe (29 characters). [48] Truncating mutations in dilated cardiomyopathy patients are most commonly found in the A region; although truncations in the upstream I region might be expected to prevent translation of the A region entirely, alternative splicing creates some transcripts that do not encounter the premature stop codon, ameliorating its effect. … Long birth names are often coined in protest of naming laws or for other personal reasons. This is sometimes referred to as agglutinative construction. Use the list below to choose the Titin Peptide and Titin Protein which is most appropriate for your research; you can click on each one to view full technical details, images, references, reviews and related products. [43], The name titin is derived from the Greek Titan (a giant deity, anything of great size). 4UOW, 1BPV, 1G1C, 1NCT, 1NCU, 1TIT, 1TIU, 1TKI, 1TNM, 1TNN, 1WAA, 1YA5, 2A38, 2BK8, 2F8V, 2ILL, 2J8H, 2J8O, 2NZI, 2RQ8, 2WP3, 2WWK, 2WWM, 2Y9R, 3KNB, 3LCY, 3LPW, 3PUC, 3Q5O, 3QP3, 4C4K, 4JNW, 4O00, 4QEG, 5BS0, Titin /ˈtaɪtɪn/, also known as connectin, is a protein that in humans is encoded by the TTN gene. [36][37][38], Drosophila Titin, also known as Kettin or sallimus (sls), is kinase-free. One who doesn’t indulge in excesses, especially food and drink; at 11 letters this is … The longest word in English has 189,819 letters and would take you three and a half hours to pronounce correctly. The titin protein is located between the myosin thick filament and the Z disk. raw download clone embed print report. Details. [6] In 1995, Labeit and Bernhard Kolmerer determined the cDNA sequence of human cardiac titin. This article incorporates text from the United States National Library of Medicine, which is in the public domain. The identity of the longest word in English depends upon the definition of what constitutes a word in the English language, as well as how length should be compared. Titin's primary functions are to stabilize the thick filament, center it between the thin filaments, prevent overstretching of the sarcomere, and to recoil the sarcomere like a spring after it is stretched. [22] It has a theoretical instability index (II) of 42.41, classifying the protein as unstable. ", "Role of titin in vertebrate striated muscle", GeneReviews/NIH/NCBI/UW entry on Familial Hypertrophic Cardiomyopathy Overview, GeneReviews/NCBI/NIH/UW entry on Udd Distal Myopathy, Tibial Muscular Dystrophy, Udd Myopathy, GeneReviews/NIH/NCBI/UW entry on Salih Myopathy or Early-Onset Myopathy with Fatal Cardiomyopathy, Serine/threonine-specific protein kinases, Non-specific serine/threonine protein kinases, 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase, (isocitrate dehydrogenase (NADP+)) kinase, Goodpasture-antigen-binding protein kinase, United States National Library of Medicine, https://en.wikipedia.org/w/index.php?title=Titin&oldid=1005641948, Wikipedia articles incorporating text from the United States National Library of Medicine, Creative Commons Attribution-ShareAlike License, This page was last edited on 8 February 2021, at 18:49. Titins, also known as connectins, are a family of giant elastic proteins first found in vertebrate striated muscle.Titin is the largest known human protein… Not all dictionaries accept it due to lack of usage. [34] Domain duplication was facilitated by the fact that most domains are encoded by single exons. Guinness World Records formerly contained a category for longest personal name used. [30] The N-terminal (the Z-disc end) contains a "Z repeat" that recognizes Actinin alpha 2.[31]. Additionally, comparisons are complicated because place names may be considered words, technical terms may be arbitrarily long, and the addition of suffixes and prefixes may extend the length of words to create grammatically correct but unused or novel words. John Horton Conway and Landon Curt Noll developed an open-ended system for naming powers of 10, in which one sexmilliaquingentsexagintillion, coming from the Latin name for 6560, is the name for 103(6560+1) = 1019683. Titin / ˈ t aɪ t ɪ n /, juga dikenal sebagai konektin, adalah suatu protein yang pada manusia, dikodekan oleh gen TTN. [40] It has a kinase domain, some Ig/Fn3 repeats, and PEVT repeats that are similarly elastic. [25] The genus name Parapropalaehoplophorus is two letters longer, but does not contain a similarly long species name. It means "Fishing Place at the Boundaries – Neutral Meeting Grounds" and is sometimes facetiously translated as "you fish your side of the water, I fish my side of the water, nobody fishes the middle". Not a member of Pastebin yet? The English language permits the legitimate extension of existing words to serve new purposes by the addition of prefixes and suffixes. [61], 1bpv: TITIN MODULE A71 FROM HUMAN CARDIAC MUSCLE, NMR, 50 STRUCTURES, 1h8b: EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN, 1nct: TITIN MODULE M5, N-TERMINALLY EXTENDED, NMR, 1ncu: Titin Module M5, N-terminally Extended, NMR, 1tit: TITIN, IG REPEAT 27, NMR, MINIMIZED AVERAGE STRUCTURE, 1tiu: TITIN, IG REPEAT 27, NMR, 24 STRUCTURES, 1tki: AUTOINHIBITED SERINE KINASE DOMAIN OF THE GIANT MUSCLE PROTEIN TITIN, 1tnm: TERTIARY STRUCTURE OF AN IMMUNOGLOBULIN-LIKE DOMAIN FROM THE GIANT MUSCLE PROTEIN TITIN: A NEW MEMBER OF THE I SET, 1tnn: Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I set, 1ya5: Crystal structure of the titin domains z1z2 in complex with telethonin, 2a38: Crystal structure of the N-Terminus of titin, 2f8v: Structure of full length telethonin in complex with the N-terminus of titin, 2ill: Anomalous substructure of Titin-A168169, 2nzi: Crystal structure of domains A168-A170 from titin. The name of the protein titn is 189,819 letters long and the longest one in English. [29] The longest hyphenated names in the U.S. are Winchester-on-the-Severn, a town in Maryland, and Washington-on-the-Brazos, a notable place in Texas history. The idea and invention of the word is credited to songwriters Robert and Richard Sherman. [12] With its length of ~27,000 to ~35,000 amino acids (depending on the splice isoform), titin is the largest known protein. The category was removed shortly afterward. Parastratiosphecomyia stratiosphecomyioides Stratiomyid Fly Soldier Fly", "What's the Name of That Lake? However, this name, proposed by B. Dybowski, was invalidated by the International Code of Zoological Nomenclature in 1929 after being petitioned by Mary J. Rathbun to take up the case.[24]. The lake is also known as Webster Lake. The full chemical name, containing 189,819 letters, is sometimes stated to be the longest word in the English language. Taumatawhakatangihangakoauauotamateapokaiwhenuakitanatahu (57 letters), which is a hill in New Zealand. Titin full chemical name for copy/paste. "Supercalifragilisticexpialidocious", the 34-letter title of a song from the movie Mary Poppins, does appear in several dictionaries, but only as a proper noun defined in reference to the song title. Titin is a protein found in muscle tissue. [42] An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Soon you’ll see why it is the largest… Titin is the short name for an extremely massive protein molecule. The longest word whose letters are in alphabetical order is the eight-letter, The longest words recorded in OED with each vowel only once, and in order, are, The longest words typable with only the left hand using conventional hand placement on a. The longest word in any of the major English language dictionaries is pneumonoultramicroscopicsilicovolcanoconiosis, a word that refers to a lung disease contracted from the inhalation of very fine silica particles,[12] specifically from a volcano; medically, it is the same as silicosis. References ^ Online 'Mendelian Inheritance in Man' (OMIM) 188840 ^ ExPASy-calculated pI for titin… The official name of the place is Llanfairpwllgwyngyll, commonly abbreviated to Llanfairpwll or Llanfair PG. Titin mutations are associated with hereditary myopathy with early respiratory failure, early-onset myopathy with fatal cardiomyopathy, core myopathy with heart disease, centronuclear myopathy, limb-girdle muscular dystrophy type 2J, familial dilated cardiomyopathy 9,[10][46] hypertrophic cardiomyopathy and tibial muscular dystrophy. The word was deliberately coined to be the longest word in English, and has since been used[citation needed] in a close approximation of its originally intended meaning, lending at least some degree of validity to its claim.[6]. It is generally agreed, however, that this invented name, adopted in the mid-19th century, was contrived solely to be the longest name of any town in Britain. Choose from our Titin … The titin domains have evolved from a common ancestor through many gene duplication events. Of the many titin variants identified, five are described with complete transcript information available. elegans. Consisting of a series of Latin words meaning "nothing" and defined as "the act of estimating something as worthless"; its usage has been recorded as far back as 1741. In order of first appearance, methionyl (which appears 337 times, including as the first component); threonyl (which appears 2083 … Titin is the third most abundant protein in muscle (after myosin and actin), and an adult human contains approximately 0.5 kg of titin. It connects the Z line to the M line in the sarcomere. [10] It limits the range of motion of the sarcomere in tension, thus contributing to the passive stiffness of muscle. Under the long number scale, it would be 106(6560) = 1039360. The length of the entire word is jaw-droppingly awe-inspiring whether it ever makes it to a lexicon or not! How to say titin in English? 'Methionylthreonylthreonylglutaminylarginyl...isoleucine' is the chemical name of 'titin' (also known as 'connectin') - the largest known protein. raw download clone embed print report. For example, the wheat chromosome 3B contains almost 1 billion base pairs,[22] so the sequence of one of its strands, if written out in full like Adenilyladenilylguanilylcystidylthymidyl..., would be about 8 billion letters long. [14][15][16], Ross Eckler has noted that most of the longest English words are not likely to occur in general text, meaning non-technical present-day text seen by casual readers, in which the author did not specifically intend to use an unusually long word. In 2011, a dictionary broke this record with a 1909-letter word describing the trpA protein (P0A877).[3]. Titin is also … Sylvia Plath made mention of it in her semi-autobiographical novel The Bell Jar, when the protagonist was reading Finnegans Wake. A Physical Map of the 1-Gigabase Bread Wheat Chromosome 3B, Methionylthreonylthreonylglutaminylalanyl...isoleucine, Lopadotemachoselachogaleokranioleipsano...pterygon, Pneumonoultramicroscopicsilicovolcanoconiosis, pneumonoultramicroscopicsilicovolcanoconiosis, Lopadotemachoselachogaleokranioleipsanodrimhypotrimmatosilphiokarabomelitokatakechymenokichlepikossyphophattoperisteralektryonoptekephalliokigklopeleiolagoiosiraiobaphetraganopterygon, Parastratiosphecomyia sphecomyioides, International Code of Zoological Nomenclature, Taumatawhakatangihangakoauauotamateapokaiwhenuakitanatahu, Llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogoch, Dysart, Dudley, Harcourt, Guilford, Harburn, Bruton, Havelock, Eyre and Clyde, Chargoggagoggmanchauggagoggchaubunagungamaugg, Learn how and when to remove this template message, List of the longest English words with one syllable, Webster's Third New International Dictionary, Donaudampfschiffahrtselektrizitätenhauptbetriebswerkbauunterbeamtengesellschaft, "Reading The Longest English Word (190,000 Characters)", "World's longest word takes 3.5 hours to pronounce", Merriam Webster: Supercalifragilisticexpialidocious, Merriam Webster: "Antidisestablishmentarianism is not in the dictionary. structural molecule activity conferring elasticity, GO:0048552 regulation of catalytic activity, skeletal muscle myosin thick filament assembly, GRCh38: Ensembl release 89: ENSG00000155657, GRCm38: Ensembl release 89: ENSMUSG00000051747, "Unfolding of titin domains explains the viscoelastic behavior of skeletal myofibrils", "Damped elastic recoil of the titin spring in myofibrils of human myocardium", "The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system", "Skinned Fibres of Skeletal Muscle and the Mechanism of Muscle Contraction－A Chronological Account of the Author's Investigations into Muscle Physiology", "Connectin, an elastic protein of muscle. Diseases associated with TTN include Myopathy, Myofibrillar, 9, With Early Respiratory Failure and Tibial Muscular Dystrophy, Tardive.Among its related pathways are Dilated cardiomyopathy (DCM) and Response to elevated platelet cytosolic Ca2+.Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein … [13] Furthermore, the gene for titin contains the largest number of exons (363) discovered in any single gene,[14] as well as the longest single exon (17,106 bp). [22] Its mouse homologue is even larger, comprising 35,213 amino acids with a MW of 3,906,487.6 Da. Check it out. It has roles in the elasticity of both muscle and chromosomes. As the largest known protein, titin has the longest full chemical name. [25] Titin consists primarily of a linear array of two types of modules, also referred to as protein domains (244 copies in total): type I fibronectin type III domain (132 copies) and type II immunoglobulin domain (112 copies). Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy", "The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin", "Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A", "Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence", "Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2", "Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly", "The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity", "Solution scattering suggests cross-linking function of telethonin in the complex with titin", "Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin", "Ask the experts - What is the longest English word? Full Name of Titin Methionylalanylthreonylserylarginylglycylalanylserylarginylcysteinylproly-... 2. Aequeosalinocalcalinoceraceoaluminosocupreovitriolic, at 52 letters, describing the spa waters at Bath, England, is attributed to Dr. Edward Strother (1675–1737). It has 189,819 letters. [23] In 1965, the Chemical Abstracts Service overhauled its naming system and started discouraging excessively long names. [26] The word is composed of the following elements: The longest officially recognized place name in an English-speaking country is a guest . It is a pretty big protein, and its full chemical name is giant as well. Titin's Chemical Name (Full Form) of 189,819 … [60] However, lexicographers regard generic names of chemical compounds as verbal formulae rather than English words. The 58-letter name Llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogoch is the name of a town on Anglesey, an island of Wales. At high extensions PEVK stretching can be modeled with a modified WLC model that incorporates enthalpic elasticity. The Oxford English Dictionary contains pseudopseudohypoparathyroidism (30 letters). [9], Titin is important in the contraction of striated muscle tissues. The full name … Alternate, but less common, approaches include phonology (the spoken language) and the number of phonemes (sounds). Reiji Natori in 1954 was the first to propose an elastic structure in muscle fiber to account for the return to the resting state when muscles are stretched and then released. The longest official geographical name in Australia is Mamungkukumpurangkuntjunya. isoleucine" … Centriole staining in human, mouse and zebrafish cells", "Nature of PEVK-titin elasticity in skeletal muscle", "Properties of titin immunoglobulin and fibronectin-3 domains", "D-Titin: a giant protein with dual roles in chromosomes and muscles", "Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation", "Human autoantibodies reveal titin as a chromosomal protein", "Whole-exome sequencing identifies a potential TTN mutation in a multiplex family with inguinal hernia", "Familial dilated cardiomyopathy locus maps to chromosome 2q31", "Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin", "HEART DISEASE.
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